Closium is a probiotic preparation containing mixture of Clostridium butyricum and Bifidobacterium. Clostridium butyricum can kill and inhibit several kinds of pathogenic bacteria such as shigella dysentery, cholera vibrion, E.Coli etc. There is not only no resistance between them, but Clostridium butyricum can also promote the growth of Bifidobacterium. Closium can treat intestinal disease as well as can adjust intestinal function. It's a new generation biopharmaceutical with three effects of therapy, prevention and health protection. Closium can be used for the treatment of acute and chronic diarrhea, enteritis, imbalance of normal intestinal flora and dyspepsia. 

Clostridium butyricum and Bifidobacterium bifidum, both bacterial strains are dominant in intestinal flora and can synergistically promote the growth of each other. With proven immunoregulatory effect and a wide range of clinical applications and evidence based support, it is a probiotic that is explicitly approved for use by the old and the young, as well as pregnant women before and after delivery.