Yes, Probiotis can be taken during a course of antibiotics, but the Probiotis capsules should be taken at least two hours before or after the antibiotics. It is recommended to continue for at least 2 weeks after you have finished your course of antibiotics. The antibiotic may affect the live cultures if taken at the same time, hence the reason to take before or afterwards. However as with other food supplements, we recommend consulting your doctor or pharmacist before using if you are under medical supervision or taking medication.